Christie Impact Report 2025

Impact Report 2024/25 Your impact

Welcome to our Impact Report for 2024/25

The Christie Charity exists solely to support the work of The Christie NHS Foundation Trust and its patients providing enhanced services over and above what the NHS funds in four main areas: research, care and treatment, education and extra patient services.

This Impact Report is our opportunity to share some of the highlights over the last year from a few of our priority funding areas and to thank our dedicated fundraisers, supporters, and volunteers for everything they have done and continue to do to ensure cancer patients at The Christie hospital receive an excellent standard of care and treatment and access to the very latest research, and that their families and carers are supported too. Thanks to the unwavering commitment and generosity of our loyal supporters, we raised a fantastic £20.8m this year. For every £1 spent or committed, 83p went directly to supporting patients, and the remaining 17p helped us raise the next pound.

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Research has been a key focus for us as part of our commitment to supporting the research efforts of the Trust with up to £30m of funding by 2030. The Trust has set ambitious targets for the next few years including trebling the number of patients participating in research, and growing the pipeline of research leaders with regional, national and international influence. Investing in people has always been crucial to the success of The Christie and this year is no different. The Charity has funded a number of clinical research fellows that play an active role in both clinical and research activities and help to improve patient outcomes through involvement in potentially practice changing research. Looking after patients emotional and mental wellbeing is as important as their clinical care and with that in mind we have recently introduced animal therapy for our younger patients. Lilo and Luna, cocker spaniel therapy dogs, visit our proton beam therapy centre every fortnight and have been a big hit with both our young patients and staff alike. As we look back with pride at the impact our supporters have made amidst a year marked by continued rising living costs, we are deeply moved by the extraordinary support, generosity, and solidarity shown. This support has made a vital difference to the lives of people with cancer and their loved ones and means Christie doctors, nurses and research teams can provide the very best care and develop life-saving and life-changing treatments which are used

not just in the UK, but across the world. The ripple effect of your kindness is immeasurable. We are incredibly grateful to everyone who has played their part. We will continue our efforts to make a difference — to patients, their families, and staff — where and when it is most needed. We will never stop looking for ways to improve the lives of people affected by cancer. THANK YOU!

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How you helped Our supporters never cease to amaze us with their enthusiasm, kindness, commitment and energy. Whether they choose to give a monthly gift, take part in an event, make a donation in celebration of a special occasion, leave a gift in their Will or donate to one of our fundraising appeals — we value each and every donation however large or small. Over the next few pages we will share stories highlighting some of the ways you have fundraised and supported the Charity and the impact of that support on the lives of cancer patients not only in the UK, but worldwide.

613 Santas took part in the Festive Dash

Over 100 tractors came together for a rally

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5,354 supporters covered 142,066km across multiple events — (3.5 times around the world)

28,134 items sold in our Charity centres at The Christie Withington and Macclesfield District General Hospital

Over 25,000 staff from over 545 businesses chose to support us

9 surgeons ran the Manchester half marathon

92 gifts from philanthropists supported 20 different projects

53 gifts were received from Trusts & Foundations supporting 16 projects

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Jan’s story

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For Jan Ross, a 59-year-old former paediatric nurse from Liverpool, taking part in a clinical trial at The Christie has been life-changing. Diagnosed with multiple myeloma — a type of blood cancer that cannot be cured but can be managed — Jan faced limited options.

But thanks to a new drug developed through a clinical trial at The Christie, supported by The Christie Charity, Jan is now in complete remission. She continues to visit the hospital every two weeks for blood tests and treatment and is enjoying a greatly improved quality of life. The trial was part of a pioneering early-phase research programme led by Dr Emma Searle, consultant haematologist and deputy medical director of The Christie’s Clinical Research Facility. With the help of Charity funding, Dr Searle and her team have been able to bring complex global trials to Manchester — often the only UK location outside London to offer such studies. These early-stage trials test new treatments in patients for the first time and are often the only option left for people with hard-to-treat blood cancers. Around 60 patients a year are now benefitting from this vital work, which is made possible thanks to the generosity of Charity supporters. “The impact of being part of this trial is huge,” says Jan. “There is hope and a new way to have a brilliant quality of life.”

PREVIOUS PAGE Jan Ross, Christie Patient LEFT Dr Emma Searle

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Alan’s story

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When Alan Traynor was diagnosed with colorectal cancer, he was referred to The Christie for specialist treatment. Under the care of consultant colorectal surgeon Mr Paul Sutton, Alan received complex surgery and expert care that he believes saved his life.

Mr Sutton is a leading specialist in advanced colorectal cancer, carrying out highly complex operations for cancers that are often difficult to treat. These include pelvic exenteration and sacrectomy, where multiple organs are removed to control disease, as well as heated chemotherapy delivered directly into the abdomen for cancers that have spread from the appendix or bowel. Thanks to funding from The Christie Charity, Mr Sutton and his team are also advancing research into how treatments can be made more effective. A key focus is combining chemotherapy, radiotherapy and immunotherapy to improve cancer response, with the aim of reducing the need for major, life-altering surgery. With Charity support, the team has established a dedicated endoscopy clinic to enable more precise, biopsy-driven research. This innovative approach has already helped patients like Alan, who says: “Paul Sutton and his team have literally saved my life. The level of care at The Christie has been amazing. They’re constantly developing treatments with the support of The Christie Charity to help more patients like me.”

PREVIOUS PAGE Alan Traynor, Christie Patient LEFT Mr Paul Sutton

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John’s story

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When John McGartland from Stalybridge was diagnosed with gastro-oesophageal junction cancer — where the oesophagus (food pipe) joins the stomach — he faced an uncertain future. But thanks to a clinical trial at The Christie, funded by The Christie Charity, John was given a new chance at life.

The trial, led by consultant medical oncologist and scientist Dr Sara Valpione, is testing a new RNA-based immunotherapy — an innovative treatment that helps the immune system recognise and fight cancer more effectively. It is designed to offer improved outcomes with fewer side effects than traditional treatments such as chemotherapy or radiotherapy. John was offered a place on the trial. “I agreed in a heartbeat and subsequently I was accepted, which gave us hope” he said. Today, John is in remission and attends regular check-ups. He credits the research, staff and care at The Christie with making his recovery possible. Research is a major focus for The Christie Charity, which has pledged up to £30 million of funding by 2030 to support more studies like this. The goal is to bring tomorrow’s treatments to patients faster, grow a pipeline of expert research leaders, and increase the number of people accessing clinical trials.

PREVIOUS PAGE John McGartland, Christie Patient LEFT Dr Sara Valpione

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Supporting young minds Thanks to the generous support of long-time donor and fundraiser, Jan Trevalyan and his partner Lisa Marriott, The Christie Charity is helping to advance crucial research into the mental health of young cancer patients.

The couple’s annual fundraising ball raised an incredible £250,000 this year, which is funding a clinical PhD student to explore the possible under-diagnosis of autism and ADHD in children and young people undergoing cancer treatment. Dr Hannah Slevin, the appointed PhD student, is leading this pioneering research. She explains, “I’m extremely grateful to Jan and Lisa and The Christie Charity for supporting my PhD. I am developing a clinical study to better understand mental health, autism, and ADHD in this vulnerable group.” “The types of cancer that affect teenagers and young adults are different from those that typically affect other age groups. They need their own research programmes and specialist care. “I’ve been looking at what research is already out there and am undertaking a detailed review. I’ve also applied to run a study

involving young people and parents, inviting them to complete questionnaires about mental health, autism and ADHD at The Christie and Royal Manchester Children’s Hospital. Plus, I’m hoping to access data from the University of Leeds that tracks cancer in children and young people in Yorkshire. My aim is to use this information to help improve support for young cancer patients who are neurodiverse.”

RIGHT Dr Hannah Slevin (centre) Jan Trevalyan and Lisa Marriott.

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A peal with a purpose Last Christmas, Ryan Battersby, a bellringer with 22 years’ experience led a team of campanologists sharing festive cheer and raising vital funds for The Christie Charity in a truly unique way.

Ryan, Tower Captain at St Bartholomew’s Church in Westhoughton, arranged a Quarter Peal — which is approximately 50 minutes of continuous ringing! He says: “Together with my team of seven campanologists we rang in over 1,200 strokes on a near three-quarter tonne bell.” This demanding marathon, reserved for significant moments in bell-ringing tradition, was to raise money for The Christie Charity, following fellow bellringer Michelle Newsham’s treatment for breast cancer at The Christie last year. “It was a ‘thank you’ for the amazing care provided to her,” explains Ryan. “It is a cause very dear to our hearts.” The event attracted both the local community and bell-ringing enthusiasts nationwide — Ryan even dressed up as Santa for the occasion!

Thanks to Ryan and his fellow campanologist’s dedication, the ‘Christmas Quarter Peal for The Christie’ raised £6,563.60 for The Christie Charity’s Breast Cancer Research Fund — far exceeding the original £2,000 target.

RIGHT Ryan Battersby and Michelle Newsham, Christie Patient

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Pippa’s story

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When Richard and Lucy Cook’s two-year old daughter, Pippa, was diagnosed with a malignant brain tumour in August 2024, their world was rocked. Following surgery at Birmingham Children’s Hospital, Pippa was referred to The Christie for 33 sessions of proton beam therapy.

The treatment, delivered at The Christie’s state-of-the-art high energy proton beam therapy centre — one of only two NHS centres in the country — helped save Pippa’s life. The centre includes a dedicated research room made possible by £5.6 million raised by supporters of The Christie Charity. It’s a space used for improving treatments and outcomes for patients. Throughout Pippa’s time at The Christie, the team went above and beyond to support the family. “Each day they played with her, supported us, and made us feel welcome,” says Pippa’s dad, Richard. “Pippa loved the playroom — she would get so excited to go there and meet the nurses, play therapists and anaesthetists who all interacted with her and treated her with respect.” Determined to show their gratitude, the Cook family signed up for The Christie Charity’s Festive Dash at Heaton Park in November 2024. Pippa, her parents, grandparents, aunty and cousin all took part, travelling from their homes in Solihull. “Everyone we came across at The Christie works so hard to make sure every family is looked after and that the children don’t feel scared about being in hospital,” added Richard. “Taking part in the Festive Dash was just our small way of contributing to The Christie Charity.”

LEFT Richard, Lucy and Pippa Cook

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A legacy of kindness After 17 months of living with adrenal cancer — a rare and aggressive cancer that forms in the adrenal glands on top of the kidneys — Claire Pearl Howell, a highly skilled PhD educated Geotechnical Engineer, died in December 2023 at the young age of 33.

Claire was extremely grateful for the wonderful treatment and support she received at The Christie. Claire was also appreciative of the support given to her parents Norman and Pearl and her sister Jayne. So, as an incredibly selfless and kind gesture, Claire made the decision to include a significant gift to The Christie Charity in her Will — alongside encouraging funeral donations — to benefit fellow patients in a similar situation to herself. Claire also supported fundraising efforts during her illness. In 2023, she cheered on her sister Jayne, and Jayne’s friend Charlotte, during their Manchester 10K run for The Christie Charity. Claire’s work colleagues at BAM Ritchies were so inspired by her courage, they donated their winnings from a company swimming challenge in her honour.

Norman, a longstanding member of the UK Society for Trenchless Technology saw the Society Council choose The Christie Charity as its Gala Dinner Partner for 2023 and 2024. In Claire’s memory, Norman, Pearl and Jayne took part in the 2025 Night of Neon 5K walking event and were supported by family and friends raising a substantial sum for The Christie Charity. “Claire was such a kind and loving person,” says her sister Jayne. “She would have been amazed at all the fantastic fundraising her family and friends have done in her memory to help others who face the daunting challenge of cancer.” Gifts in Wills support one third of The Christie Charity’s projects.

RIGHT Norman, Pearl and Jayne Howell

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Tackling cancer head on When Chris Bamber’s wife, Sarah, was diagnosed with incurable breast cancer and became a patient at The Christie, he turned his personal grief into an incredible force for good. A long-standing figure in Manchester’s rugby community, Chris from Stalybridge used his network and passion for the sport to fundraise for The Christie Charity.

What began as a single charity match — organised with his friend Nick Ryan’s company, City Recruiter, and Greater Manchester Police — has grown into an annual event that unites players, businesses, and supporters for one cause. With £80,000 already raised, the tournament continues to build momentum each year. Chris and Sarah’s story inspired many, including employees at Tesco, where Sarah worked as a director. Moved by her courage and the exceptional care provided by The Christie, Tesco staff across the country organised bucket collections, creating a separate wave of grassroots fundraising that spread nationwide. “People have been incredibly generous and supportive — it’s honestly been overwhelming,” says Chris. “When Tesco got involved, we saw bucket collections happening everywhere, from the Scottish islands all the way down to Cornwall. It just

shows how far-reaching Sarah’s story and The Christie Charity’s impact really are.” “We were aiming to make £10K in our fundraising and we’ve made over eight times that amount so far. It means so much to know that so many people are behind us, helping to make a difference.”

RIGHT Chris Bamber

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Loving husband honours wife’s memory Mike Rooney’s pledge to honour his late wife Janet’s memory has created a lasting legacy for patients with rare and hard-to-treat cancers.

After losing Janet to bile duct cancer in April 2023, Mike from Todmorden channelled his grief into action. Alongside close friends, he raised over £100,000 for The Christie Charity — funding the creation of The Janet Rooney Fellowship. This vital funding enabled The Christie to appoint Dr Eleni Vrana as a clinical research fellow focusing on hepato-pancreatico biliary (HPB) cancers, which are cancers that start in the liver, pancreas, or bile ducts and neuroendocrine tumours (NETs) which are rare cancers that develop from cells in the body that produce hormones and are most commonly found in the digestive system or lungs. These are both complex and under researched disease areas. Originally from Greece, Dr Vrana says: “The Janet Rooney

Fellowship is giving me the chance to contribute to critical advancements in the diagnosis and treatment of HPB cancers and NETs. I’m deeply grateful to Mike and his fundraisers for this opportunity.” Mike’s fundraising efforts included a major charity dinner and a 500-mile trek across Spain’s Camino de Santiago, completed with friends Nigel Tobias and David Brooks. “Janet’s cancer was difficult to detect, and there’s so little research into bile duct cancer,” says Mike. “I wanted to change that. Knowing this fellowship could help others is incredibly meaningful.”

RIGHT Mike Rooney and Dr Eleni Vrana

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Emotional support for young patients

The Peel Group Foundation’s generous funding has helped The Christie Charity support a vital psychological service for young patients aged 16–24 on the Teenage and Young Adult (TYA) unit.

For 25-year-old teaching assistant Demisha Patel, diagnosed with a brain tumour in 2023, this service became a lifeline. Led by consultant clinical psychologist Dr Louise Robinson, the service offers one-to-one, and group therapies tailored specifically to the unique emotional, social and developmental challenges faced by young people with cancer. Since launching in late 2022, it has supported 90 patients across more than 600 sessions. During her treatment at The Christie, the bespoke psychological support helped Demisha manage intense anxiety and regain a sense of control. “Talking to Louise gave me comfort I couldn’t get from family,” she said. “It was a safe space. She brought me back to the ‘right now’ when my mind was a bit crazy.”

Kate Holland from The Peel Group Foundation said: “The Christie Charity has been a long-standing partner of Peel, and this particular project really resonated with us. It’s hard to imagine the emotional impact of receiving a cancer diagnosis at any time — especially during the teenage years. The new TYA psychological service is already making a meaningful difference in the lives of young people, offering specialist support at a time when they need it most. We are truly grateful to play a part in helping to make this vital service available.” It’s thanks to partners like the Peel Foundation that young people like Demisha receive the care they need, when they need it most.

RIGHT Kate Holland

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Looking to the future

Experimental, pioneering and life-changing research

Total Body PET CT scanner Rapid access to high quality imaging is key to cancer treatment. At the moment, Greater Manchester struggles to keep pace with demand and has limited research PET CT (Positron Emission Tomography — Computed Tomography) scanning capacity. We are investing in a state-of-the-art, high-capacity Total Body PET-CT scanner which will meet the future needs of patients and ensure that The Christie remains at the forefront of this service. Total Body PET-CT scanners are a recent innovation and represent the state-of-the-art in PET-CT technology. Having very sensitive detector arrays which capture and convert incident radiation or particles into electrical signals, they are able to scan most of the body at once. This can then be used to generate PET-CT scans in around five minutes compared to the usual 20 mins, increasing the number of patients that can be scanned, and significantly reducing the radiation dose to the patient. There are currently only four of these scanners in the UK (three in London and one in Edinburgh). Only two in London are focused on delivering care to NHS patients. The Total Body PET-CT

The next five years will see a particular focus on supporting The Christie NHS Foundation Trust’s research team and realising the potential of the Paterson building with the ultimate aim of bringing tomorrow’s treatments to patients faster. The Christie Charity will support the Trust’s transformational investment of £30m in research to support the Trust’s vision of: • learning from every patient • enabling every patient to participate in research • applying this knowledge to improve the lives of patients with cancer now and in the future This investment will further position the Trust’s research offering as experimental, pioneering and life-changing and will treble the number of patients participating in research with the ultimate aim of enabling every Christie patient to participate in research, while also growing the pipeline of research leaders with regional, national and international influence.

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RIGHT Artist’s impression of the new Pathology Centre

scanner in Manchester will be a flagship facility for the North, demonstrating the value of state-of-the-art PET-CT in providing for a diverse population with a wide range of significant health needs. We hope to have the scanner operational by Summer 2026. Pathology development Pathology, which involves examining cells and tissue and providing testing and screening (including for clinical trials), is essential to every patient’s journey at The Christie. The hospital currently conducts over 1 million tests annually, and as a leading provider it also serves other hospitals regionally and nationally. The current location and condition of the pathology department is no longer fit for purpose in terms of its size, layout and the ability to house new technology. The development of a new pathology centre will improve the patient experience and facilitate high quality research in line with our Charitable objectives. Once operational, the new pathology facility is expected to significantly increase sample throughput and turnaround times,

all without the need to increase staffing levels. The building will sit alongside a new cutting-edge scanning centre which has already received planning approval. One of the key elements of our strategy is to explore new ways of income generation. Social investment is investment that’s intended to deliver a positive social impact, as well as a financial return on the original investment. The construction of the new pathology facility is the Charity’s first social investment opportunity and will be managed by Northern Pathology Developments Limited, which is a subsidiary of The Christie Charity. We hope to explore other social investment opportunities in the near future. It is anticipated that work will begin onsite in Autumn 2025 and complete by Autumn 2026.

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Thank you

We would like to say a very special thank you to everyone that has supported us this year. The overwhelming support we receive means we can only include those who have raised £4,000 or more in this list, but rest assured whatever your contribution we are truly grateful. Your generosity brings us one step closer to a future without cancer. We would also like to acknowledge every legacy gift and pledge received. Each and every person who generously included a gift in their Will is helping to change lives.

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Gaynor Cartwright, Family and Friends Geoffrey Cawte Geoff Scargill George Elias Charitable Trust Gerald and Barbara Phillips Granville Campbell for Melvina and Eric H Hamish’s MARVELous Night Out Hard Rock Cafe Heywood Pension Technologies Hope Direct Local, Community Interest Company Horwich Farrelly Houghton Dunn Charitable Trust Howard Gill I Ian Smith and Dunham Forest Golf and Country Club Irish Association Golfers Manchester Isle of Man Anti-Cancer Association J Jack Pritchard Jacqueline Anne Clift Jake, Sam and Alex — Team Adele James Stewart Jewson

David Slack Charity Golf Day Debbie Worthington and friends Denholm Good Logistics Dorothy Marsh Duncan and Alison Bown and friends E Ecapital Commercial Finance (North) Limited Edith Murphy Foundation Edward Holt Trust Elizabeth Sarah Lammas Elliot Vure F Family & friends of Jyoti Mistry Family and friends of Victoria McDowell Fleetwood Cancer Research Committee

A Adelphi Group Airswift Altrincham and Sale Fundraising Group Altrincham vs Cancer Azra Furheen, Family & Friends B Barry Bown Bolton Unitarians Brian and Noreen Morton Brian Wilson Charitable Trust British Gas Services & Solutions Team Broken Cross Club, Macclesfield C Carl Eaton, Peter Walsh, family and friends

Carol Briggs Charlie Balls Charlotte Humphreys in memory of Christine Moss Chris Syddall, Family and Friends Christie Appeal Macclesfield Christie Bears Knutsford Claire Pearl Howell Connor Robinson D Daniel Hamburger Davenport Golf Club David, Matthew and Oliver Millar David and Myra Garlick

Frank and Gail and members of Fairfield Golf Club Audenshaw Franklyn and Olwen Baker Friends and family Chantel Neal Friends and family of Dave Marlor Friends and family of Sarah Harding Friends and family of Siobhan Moore Friends and family of Stephen Nicholl Friends and family of Suzanne Hames

Friends of Sarah McEvans Friends of Terence Burridge G Gary Tipper Gatley Open Gardens

Joe and James Dodd Joel, Joe, JJ & James Jonathan and Elly Hutton

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Pseudomyxoma Survivor Q Quest Trust R

Jon Hutton and Tim Shaw Joseph Holt Ltd Julie Hamill — All About Andy Rourke Festival June Irwin K Kai Solway Karen Barlow Karen Vernon Kate Davison and the friends, family and colleagues of Gregg Davison Kay Morris Kazuaki and Marie Tazaki Ken Matthews L Law Print & Packaging Management Ltd Linda Lam — Rainbow 88 Locky Hall with Consensus Workspace Loretta and Patrick Mooney Luke Willacy K2B M Manchester PA Network Manchester Select Rugby League March for Maddie Mark Dutton & team Mary Kendal Matt Heywood and team, family, friends and Co Maurice Miller Meg & Jamie for Carol Nadin Michael Haynes

Mike and Janelle Howard Mike Wildgoose BEM Mina Damani, family & friends M J Kirchin MRJ Recruitment MRK5 Fitness N Nantwich Christie Hospital Support Group Neal Matley & Marcus Matthews NFU Mutual Knutsford Nicola Washbrook and friends Nigel and June Chadwick Norton Barrie O Oddfellows Combermere District Ollie Kershaw Owd Codgers and friends P Pageant Girl Ltd Palatine Ward

Rachel Lee always in our hearts Rick Hickman Charity Golf Day Robert Pope, family & friends RSM UK Run for Elijah Ryan Battersby, supported by friends & community S Sam Everton, Charlie Everton & Nick Everton Sandbach Young Farmers Sandra Lomax Sarah Irlam Sebastian Clegg Showcase Sibo and The Triathlon Lads SIEMENS Simeon Mclean, son of Clarence Simsport Racing International: for Gareth Longden Sir Donald and Lady Edna Wilson Charitable Trust Skye, Kiki, Summer and Blake Trevalyan Sophie Taylor Stephen Greaney Steve and Paul Bates

Paula Nelson, Family & Friends Paul Keefe, family and friends Peter Kershaw Trust Peter Robinson, family & friends Phil Evans & Team Natwest

Phil Sayle K2B PLS Solicitors

Pop At The Lock, Linda Yarwood, Kevin Birchall & Gareth Williams

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Vinci Building and IHP Vital Energi W Warren Heyman and Anthony Davis: Football Prediction Competition Waters Corporation West Didsbury and Chorlton FC WG Lever Charitable Trust Worsley Wanderers WWCB Promotions Wych Malbank (Nantwich) Rotary Y YFM Equity Partners Yoga on The Edge Yvonne Brown, Family and Friends Z

The family and friends of Reggie Kubi The Family of Anthony Bowes The friends & family of Elaine Jepson The friends and family of Barry Kelly The friends and family of Laura Hudson The Jolly Foundation The Jon Moulton Charity Trust The Kingsley Family The King’s School in Macclesfield The Lever Family The members of Astbury Golf Club The Mike Jones Charity Golf Day The Milk Maid Marchers The Okell Trust The Peel Group Foundation The Sir Edward Lewis Foundation The Steve Burne Charitable Trust The Steve Prescott Foundation The Stoller Charitable Trust The Syncona Foundation The Wibbersley & Thorne Society The Widows Walking The Zochonis Charitable Trust THG Thomas Relph in Memory of my dad Mark Transport for Greater Manchester Trimont V V7 Recruitment

St Thomas More RC College — Denton Stuart Hale Subvert Boardstore Suresh S Patel Suzanne Muriel Darbyshire T Team Isobel De-koning Team Jane, Sally, Rachel & Bethan Team Loz Team Morris TeamWest Tesco Tesco Altrincham Tessa Whiskard The Castanea Trust The Colleagues and Family of Karen Margaret Roach The DDC Group The family and friends of Andrew Donaldson The family and friends of Carly Sigley The family and friends of Catherine Sarah Isherwood The family and friends of Christine Somers The family and friends of Emily Mason The family and friends of Harvey Mitchell The family and friends of Lauren ‘Lol’ Lasko The family and friends of Mark Petrie The family and friends of Mark Varden The family and friends of Paul Hodgson

Zara Grospellier Zerum & Mosodi

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