Public BoD papers 28.04.22

response adapted design in the first-line treatment of patients with classical Hodgkin lymphoma unsuitable for chemotherapy due to age, frailty or comorbidity (BREVITY) (Adam Gibb, British Journal of Haematology) • Second-line FOLFOX Advanced biliary tract cancer 2L phase III trial (Angela Lamarca, Lancet Oncology) 8. Develop patient and public involvement and engagement The Christie Clinical Trials Patient and Public Involvement (PPIE) Group was established on November 16, 2020: initially 3 members and now 6 who meet monthly via MS teams The group has provided feedback on questionaires, information sheets, side effects and study procedures for the following studies o CONNECT Study - COVID-19 and technology and the impact on Clinical Trial patients o BI 1472-0001 Study – Phase 1a/1b study to test different doses of BI 1823911 alone and combined with other medicines in people with different types of advanced cancer with KRAS mutation (The group persuaded the pharma sponsor to reduce 6 patient information sheets to one single information sheet) Engagement : o Virtual patient and public engagement event on ‘Understanding Cancer Clinical Trials’ - 21/4/2021. Future strategy and potential impact Going forward, it is planned to have at least 8-10 PPIE members with representation from different backgrounds including underrepresented Black, Asian and minority ethnic (BAME) groups to support the growing portfolio of research, intensive nature of early phase trials and to promote holistic care to all research and trial patients at The Christie.

Recommendation Board are asked to note the progress against the objectives in The Division of Research and Innovation.

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