Public BoD papers 28.04.22

• New funding awards totalling £2.5 Million were obtained for the PROTIS trial from Cancer Research UK and the TOURIST trial from National Institute for Health Research-Health Technology Assessment (NIHR-HTA). PROTIS, led by Dr David Thomson will evaluate proton beam radiotherapy for treatment of sino-nasal (head and neck) cancer. TOURIST, led by Dr David Woolf and designed in collaboration with the National Cancer Research Institute (NCRI) Lung research group will define the impact of radiotherapy treatment in 1000 patients nationally with advanced, metastatic lung cancer. Enabling Innovation • November 2023: A joint working partnership with a Pharma partner has been established to improve follow up care for patients with breast cancer and utilising EPROMS • April 2022: A commissioned funding submission to NHSE for a Trusted Research Environment for real world data from patients treated with proton beam therapy Translational research • There are currently 60 active sample collection projects implemented by The Manchester Cancer Research Centre Biobank team led by Jane Rogan Peer -reviewed publications 2021 • Total ~ 400 (Selected publications Table 7) Research Excellence Framework (REF) • The University of Manchester REF return was submitted in March 2021; eight cancer specific research impact case studies of which 6 were directly attributable to Christie academic researchers. Results pending Spring 2022.

Table 6: Christie Sponsored Studies Launched in 2021 Short title Objective

Lead Investigator Dr Manon Pilai

Domain

NOTION

Home monitoring of blood for early detection of side effects from immunotherapy in patients with renal cell cancer and melanoma Impact of digital technologies on care (Christie charity funded) Aims to improve bone health following pelvic radiotherapy (Medical Research Council Funded)

Medical Oncology Systemic Therapy Research Renal Cancer Melanoma

CONNECT

Dr Donna Graham Medical Oncology Experimental Cancer Medicine Team

RADBONE

Dr Claire Higham

Supportive Oncology Endocrinology Gynaecological Cancer Living With and Beyond Cancer Radiotherapy Related research Patient Centred Medical Oncology Haematology Oncology Medical Oncology Experimental Cancer Medicine Team Research MR-Linac

MR-LINAC

A research programme to optimise delivery of radiotherapy by Magnetic resonance imaging (MRI-LINAC)

Dr Cynthia Eccles

LWBC

Survivorship needs in patients with Hodgkins Lymphoma

Dr Kim Linton

CUP-COMP Designed to improve knowledge of carcinoma of unknown primary site, an under-researched cancer associated with very poor outcomes - funded by Innovate UK

Dr Natalie Cook

67