Public BoD papers 28.04.22

- appointment of a dedicated project manager for radiology working within both R and I and radiology to expedite and coordinate research operations Activity and performance A high level of research activity was maintained through COVID after an initial dip in the second quarter of 2020 when clinical research was paused. A further pause for ~ 2 weeks occurred in late December 2022 (omicron wave). • The past year has seen a 35% increase in activity (Table 1) • The current research portfolio spans nearly 1000 studies, with 54% hosted for commercial sponsors and 75% reportable to NIHR (Table 2) • There has been a 400% increase in the number of patients screened for clinical trials of investigational medicinal products (complex studies) in the past year (Table 3) • The annual number of patients participating in interventional trials is recovering to pre–covid rates (Table 4) • The Christie has the highest activity of specialist cancer centres / trusts for performance in initiating clinical research, and delivery in recruiting to time and target has been maintained at 52.2% of studies; a rate slightly higher than other cancer centres and in line with expected for the mixed portfolio of clinical studies represented. (NIHR analyses data submitted quarterly - Table 5) • The Christie was the highest recruiting centre nationally for radiotherapy related clinical trials

Table 1: Number of new research studies initiated: a 35% increase in 21/22 Pre-Covid Covid

Post-Covid 2021/2022

2019/20

2020/21

98

86

135

Table 2: Studies by phase in set-up, open to recruitment or in follow-up (not recruiting but active treatment or survival follow-up). Of these 75% are reportable to the NIHR. All Phase I Phase II Phase III Phase IV Observational / other Total (%) 913 142 (16) 236 (26) 309 (34) 11 (1) 202 (22) Commercial (%) 494 (54) 118 (83) 125 (53) 210 (68) 9 (82) 27 (13) Academic sponsor (%) 412 (45) 24 (17) 111 (47) 95 (31) 2 (18) 175 (87)

Table 3: Annual number of patients screened to participate in research Type of Research Pre- Covid

Covid Post- Covid 2019/20 2020/21 2021/22

Clinical trial of an investigational medicinal product (CTIMP) Trial not involving an investigational medicinal product (non- CTIMP)

1891

412 219

1606

217

412

Other e.g observational, questionnaire

2029 4137

4243 4874

1891 3909

TOTAL number of patients

Table 4: Annual number of patients enrolled in a research study Type of Research

Pre- Covid Post- Covid 2019/20 2020/21 2021/22 Covid

Clinical trial of an investigational medicinal product (CTIMP) Trial not involving an investigational medicinal product (non-

704 102

358 123

408 271

64