HSS CPOC Service Annual Report 2021

Service Report May 2021 Colorectal and Peritoneal Oncology Centre – The Christie NHS Foundation Trust

NIHR (2019-2022), Cytoreductive surgery with hyperthermic intraoperative peritoneal chemotherapy versus standard of care in people with peritoneal metastases from colorectal, ovarian or gastric origin: Systematic review and individual participant data meta-analyses of effectiveness and cost-effectiveness (S O’Dwyer & O Aziz, Award value £305,636) NIHR RfPB (2019-2022) , (PrefCoRe): Quantifying and implementing preferences for the treatment of high-risk rectal cancer (A Renehan, Award value £248,879) Ileostomy Association/Medtronic (2019-2021), DiSCO- Defining standards in colorectal prehabilitation. (R Fish, Award value £10,488) MRC National Productivity Investment Fund (2017-2022), Mass Spectrometry Imaging for Colorectal Cancer Subtype Classification (O Aziz, Award value £75,000) NIHR (2017-2020) Single Use Negative pressure dressing for Reduction In Surgical site infection following Emergency laparotomy- the SUNRRISE Trial (H Clouston, Award value £345,669) 5.5Publications 2019-2021 Abudeeb H, Selvasekar CR, O'Dwyer ST, Chakrabarty B, Malcolmson L, Renehan AG, Wilson MS, Aziz O. Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for perforated low-grade appendiceal mucinous neoplasms. Surg Endosc. 2020 Dec ;34(12):5516 5521. doi: 10.1007/s00464-019-07349-x. Epub 2020 Jan 28. PMID: 31993814; PMCID: PMC7644477. Arjona-Sanchez A, Aziz O, Passot G, Salti G, Esquivel J, Van der Speeten K, Piso P, Nedelcut DS, Sommariva A, Yonemura Y, Turaga K, Selvasekar CR, Rodriguez-Ortiz L, Sanchez-Hidalgo JM, Casado-Adam A, Rufian-Peña S, Briceño J, Glehen O. Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for limited peritoneal metastasis. The PSOGI international collaborative registry. Eur J Surg Oncol. 2020 Dec 2 :S0748-7983(20)31036-2. doi: 10.1016/j.ejso.2020.11.140. Epub ahead of print. PMID: 33298341. Barriuso J, Nagaraju RT, Belgamwar S, Chakrabarty B, Burghel GJ, Schlecht H, Foster L, Kilgour E, Wallace AJ, Braun M, Dive C, Evans DG, Bristow RG, Saunders MP, O'Dwyer ST, Aziz O. Early Adaptation of Colorectal Cancer Cells to the Peritoneal Cavity Is Associated with Activation of "Stemness" Programs and Local Inflammation. Clin Cancer Res. 2021 Feb 15 ;27(4):1119-1130. doi: 10.1158/1078-0432.CCR-20-3320. Epub 2020 Nov 30. PMID: 33257424. Dames NB, Squire SE, Devlin AB, Fish R, Bisset CN, Tozer P; Respondents to the Sex After Colorectal Surgery Survey. 'Let's talk about sex': a patient-led survey on sexual function after colorectal and pelvic floor surgery. Colorectal Dis. 2021 Feb 22 . doi: 10.1111/codi.15598. Epub ahead of print. PMID: 33615666. Evans T, Aziz O, Chakrabarty B, Wilson MS, Malcomson L, Lavelle C, O'Dwyer ST. Long-term outcomes for patients with peritoneal acellular mucinosis secondary to low grade appendiceal mucinous neoplasms. Eur J Surg Oncol. 2021 Jan ;47(1):188-193. doi: 10.1016/j.ejso.2020.10.020. Epub 2020 Oct 16. PMID: 33092969. Gurusamy K, Vale CL, Pizzo E, Bhanot R, Davidson BR, Mould T, Mughal M, Saunders M, Aziz O, O'Dwyer S. Cytoreductive surgery (CRS) with hyperthermic intraoperative peritoneal chemotherapy (HIPEC) versus standard of care (SoC) in people with peritoneal metastases from

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