HSS CPOC Service Annual Report 2021

Service Report May 2021 Colorectal and Peritoneal Oncology Centre – The Christie NHS Foundation Trust

ALSGBI LapPass course (March 2021), Regional Laparoscopic Training Day, Whiston Hospital, Merseyside (C Selvasekar) MCh virtual teaching (2020-21), Edge Hill University (C Selvasekar) ALSGBI Basic Robotic Course (Dec 2020), Northwick Park & St Mark’s Hospital, Middlesex (C Selvasekar) Key Skills Course: 6th, 7th and 8th November 2020 (Nov 2020) (C Selvasekar) MRCS OSCE Preparation Course (RCSEd) (Sept 2020), Apollo Buckingham Health Science Campus, Crewe (C Selvasekar) FRCS (Gen Surg) Exit Exam Viva Course (Sept 2020), Apollo Buckingham Health Science Campus, Crewe (C Selvasekar) MRCS OSCE Preparation Course (RCSEd) (Aug 2020), Apollo Buckingham Health Science Campus, Crewe (C Selvasekar) 5.2Research We continue to expand our research portfolio. Over the past year we have established The Christie Colorectal and Peritoneal Oncology Centre (CPOC) Academy and Lab, at the Manchester Cancer Research Centre. Despite the challenges of the pandemic, we have grown our collective research team which now comprises of; 5 PhD students, an academic clinical lecturer (50% clinical/50% academic), 2 postdoctoral research fellows, and a research manager. This team is funded through the grants listed in section 5.5. Our key research themes include: (i) Biomarker research (ii) Technology and Innovation (iii) Clinical outcomes and treatment effects 5.2.1Biomarker research Cancer Research UK Accelerator Award: Pseudomyxoma peritonei: building a European multicentric cohort to accelerate new therapeutic perspectives – We are one of three European groups (including Italy and Spain) that have been awarded this prestigious award to accelerate the collection of a comprehensive biobank of tissue from patients with pseudomyxoma peritonei (PMP) from Low-grade appendiceal mucinous neoplasms (LAMNs) over 5 years. The £2.5m award aims to identify genomic biomarkers, build in vitro 3-D models and organoids, and ultimately establish a platform to identify therapeutic options for PMP patients. Our team includes faculty from across The University of Manchester including; CPOC Lab at The Manchester Cancer Research Centre, Wellcome Trust Centre for Cell Matrix, School of Pharmacology, and Manchester Centre for Genomic Medicine. The project has to date established a standardised biobank collection process, tumour sampling, DNA and RNA extraction across the 3 countries. We are now looking to standardise live tissue processing and cell culture leading to the development of LAMN in vitro models and organoids. Ultimately this project will lead to the establishment of libraries of information that can be shared with researchers across the world to accelerate our understanding of LAMNs leading to PMP.

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